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Cenforce 100mg (manufactured by Centurion Laboratories) is a generic brand name for Sildenafil Citrate (Viagra) and used to take care of sexual powerlessness such as erectile dysfunction and impotence in men. This prescription has modernized the way physicians treat men affected from erectile dysfunction . For the first time, a powerful oral medicine is on hand over the internet that is able to strikingly perk up sexual activity in over 80% of the men with (ED).

It is recommended to have one tablet of Cenforce for about 30 to 45 minutes ahead of an anticipated sexual activity. Cenforce hangs about for 4-6 hours. Do NOT take more than one pill within a period of 24 hours. This dose should be taken orally. The prescription may take a little longer to kick in if used after a big meal.

As a member of the PDE-5 inhibitors family, Cenforce has the same side effects like Viagra or any other ED medicine containing Sildenafil as an active ingredient may cause: dizziness, red face, stuck or stuffy nose while breathing, unclear vision, back or leg pain, severe headache, severe nausea, pain in the arm, jaw or neck, tingling, etc.

The History of Viagra

Sildenafil is a recognized treatment for patients suffering from erectile dysfunction. However, evidence suggests that it may have also a neuroprotective and a neurorestorative role in the central nervous system. Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity and memory consolidation. PDE5 inhibitors have gained increasing attention as a potential therapeutic target for several adult central nervous system diseases: multiple sclerosis, Alzheimer’s disease, epilepsy, memory dysfunction. Through inhibiting this enzyme, sildenafil may exert neuroprotection and neurorestoration and also enhance memory and learning. Preclinical data suggest that sildenafil may be a good candidate for the prevention or repair of brain injury.

Cellular mechanism associated with the neuroprotective effect of sildenafil.

References: 

1. The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction

2. PDE5 inhibitors – pharmacology and clinical applications 20 years after sildenafil discovery

3. USE OF SILDENAFIL CITRATE FOR TREATMENT OF ERECTILE DYSFUNCTION OF VARIOUS ETIOLOGY

4. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis

5. Sildenafil for the Treatment of Alzheimer’s Disease: A Systematic Review

6. The Role of Sildenafil in Treating Brain Injuries in Adults and Neonates

7. Sildenafil-Mediated Neuroprotection from Adult to Neonatal Brain Injury: Evidence, Mechanisms, and Future Translation

8. Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease

9. Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke in Rats

10. PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease