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PRL-8-53 (methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 by the Dr Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. It is named for Pacific Research Labs, the entity who owned the patent for the drug.
Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%. Many individual nootropic users who have tried PRL-8-53 confirm its memory-boosting effects, in some cases comparing it to a more powerful version of other nootropics such as nefiracetam and Noopept.
Mechanism of Action:
PRL-8-53’s exact mechanisms of action are not well understood, but it is believed to regulate the brain’s production of and response to several crucial neurotransmitters. In his reports on human and animal studies, Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain’s response to acetylcholine. In result the drug is capable of facilitating the conversion of short-term to long-term memory. According to the human study, there were no side effects observed when taking a dose of 5 mg of PRL-8-53. Animal studies showed that any toxic effects appear only at 1000x the recommended dose for humans.
PRL-8-53 dosage 5mg
CAS 51352-88-6
Formula C18H21NO2
Mass 283.3 Da
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  1. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent.
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