Description

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(Coluracetam bulk powder)

Coluracetam (MKC-231, BCI-540) is a nootropic in the racetam family. It was touted as the first high affinity choline uptake enhancer even though other racetams share this action. It was developed by the Mitsubishi Tanabe Pharma Corporation and put through trials to treat Alzheimer’s disease. What was found during the trials though was that it looked to improve depression symptoms and anxiety. Subsequent studies have shown that it may induce long-lasting cognitive improvements of the choline system. Typical Coluracetam dosage is 5-35mg.

Mechanism of action

As with many of the racetam compounds, Coluracetam elevates the body’s choline uptake, while also increasing the uptake in damaged neurons. The compound targets and interacts with the high affinity choline uptake (HACU) process, which is the mechanism for absorbing choline into neurons. The uptake increase happens during the Acetylcholine synthesis process. Because Coluracetam improves the preservation of choline during this process, the result is that a larger amount of choline is converted into Acetylcholine. The beneficial yield from the process incudes an increased amount of attention and alertness, along with improvements to memory. Research shows that Coluracetam also improves α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) potentiation, a receptor for glutamate that aids in synaptic transmission in the central nervous system process that boosts alertness and cognitive functions. Users buy Coluracetam for its benefits:

Benefits:

• Cognitive improvements

• Improved attention

• Improved productivity

• Mood boost

• Glutamate neuroprotection

Coluracetam Dosage  5-35mg

CAS 135463-81-9

Formula C₁₉H₂₃N₃O₃

Mass 341.404 Da

Synonyms MKC-231, BCI-540

References:

1. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.

2. MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.

3. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats.