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Metformin (HCl): a biohacker dream come true…

  Glycoheal 500 by: Healing Pharma (blisters 20 x 500mg)


Metformin was introduced to the world in 1957, as an antihyperglycemic agent by the French physician Jean Sterne. It originates from Galega officinalis, also known as the French lilac, a plant that has been used in folk medicine for centuries:

It’s the most common first-line drug to control diabetes that enhances the action of insulin. Metformin’s benefits may extend far beyond diabetes. Drug does more than decreasing the amount of glucose produced by the liver and improving the body’s sensitivity to insulin. Recent research has unveiled a fascinating aspect of this medication that extends beyond its conventional use. With the epidemiological, preclinical and clinical evidence of metformin exhibiting beneficial effects beyond glycemic control in diabetics, it has been suggested to be repurposed against cancer and its recurrence, cardiovascular disease, neurodegenerative diseases, autoimmune diseases and most recently, systemic aging as a whole.

Moreover, Metformin is the first drug to be tested for its age-targeting effects in a large clinical trial. The precise mechanisms through which Metformin may influence longevity are not yet fully understood. However, research suggests that this medication may exert its effects through multiple pathways including: improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence.

Preclinical studies have also shown some evidence of metformin’s neuroprotective role in Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and Huntington’s disease. Its anticancer, antiproliferative and apoptosis-inducing effects on malignant cells might prove instrumental in the malignancy of organs like the breast, kidney, brain, ovary, lung, and endometrium. It’s why a Metformin is proposed to be an “anti-aging” drug and closest thing to a Wonder Drug for biohackers. Metformin appears to be a promising candidate as a life-extending drug. What about side effects? The safety of metformin is quite good. Side effects may include: nausea or diarrhea. More serious side effects like allergic reactions are rare.

To get the most out of Metformin’s anti-aging properties you should combine it with vitamin B12 supplements.





Tim Ferriss in “Tools of Titans” reported about dozens of experts who trust Metformin for longevity. The list of these experts includes:


David Sinclair, Ph.D. – 1000mg per day

Nir Barzilai, M.D. – 1500mg per day

Ray Kurzweil – 500-850mg per day

Jay Campbell – 1000-2000mg per day




Main anticancer mechanisms of action of metformin. Drug can combat cancer by affecting metabolism, epigenetics, cell cycle, migration, metastasis, cell death, cell senescence, cancer stem cells, immunity, and gut microbes






Metformin dosage 500-1000mg
CAS 1115-70-4
Formula C4H11N5 · HCl
Mass 129.167 Da
Synonyms N,N-dimethylbiguanide, Fortamet, Glucophage, Glumetza


  1. Benefits of Metformin in Attenuating the Hallmarks of Aging
  2. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
  3. Metformin and Aging: A Review
  4. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
  5. Metformin: Is it a drug for all reasons and diseases?
  6. Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis
  7. Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
  8. Metformin as a booster of cancer immunotherapy
  9. Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
  10. The Use of Metformin to Increase the Human Healthspan
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