Pharmacological properties of piracetam-like compounds

CompoundIUPAC namePotencyDosageBioavailability (%)Half-life
Piracetam2-oxo-1-pyrrolidineacetamideLow50 to >300mg/kg/d (up to 37 g/d)~1004–5h
Oxiracetam2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamideMedium25–40mg/kg/d (up to 2.4 g/d)~753–6 h
PramiracetamN-[2-(dipropan-2-ylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamideMedium10–20mg/kg/d (1.2 g/d)~1002–8 h
Aniracetam1-[(4-methoxybenzoyl)]-2-pyrrolidinoneMedium12–25mg/kg/d (1.5g/d)~111–2.5 h
Phenylpiracetam2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamideHigh 2.5–5mg/kg/d (up to 0.75 g/d)~1003–5 h
Levetiracetam(2S)-2-(2-oxopyrrolidin-1-yl)butanamideMedium20–60mg/kg/d (up to 3 g/d)~1006–8h
Brivaracetam(2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamideMedium10–25mg/kg/d (up to 1.4 g/d)~907–8 h
Seletracetam(2S)-2-[(4R)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamideHigh0.03–10mg/kg/d (up to 0. 6 g/d)>908 h
NefiracetamN-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamideMedium10–15mg/kg/d (up to 0.9 g/d)NA3–5 h
Nebracetam4-(aminomethyl)-1-benzyl-pyrrolidin-2-oneMedium200–800mg/dNANA
Rolipram4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-oneHigh0.75–3.0mg/d>702h
Fasoracetam(5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-oneHigh100mg/d79–974–6.5 h
Rolziracetam2,6,7,8-tetrahydro-1H-pyrrolizine-3,5-dioneNANA~90<25 min